Discovered in the beginning of the 20th century, nicotinamide adenine dinucleotide (NAD+) has evolved to being an essential cosubstrate for a wide range of regulatory proteins that are widely recognised regulators of metabolic function and longevity.
NAD+ is widely researched among the leading scientific community and is often referred to as the “youth molecule’’ or the “Fountain of Youth” for its anti-aging benefits.
WHY WE NEED NAD+
After the age of 40 our NAD+ levels decline rapidly. By the age of 50 a typical person may have only half of the NAD⁺ they did in youth. By age 80, NAD⁺ levels can drop to only 10%, compared to the levels expressed in youth.
Deficiency of NAD⁺ predisposes us to accelerated aging and impedes our ability to fully benefit from resveratrol and its antioxidant and anti-inflammatory properties to protect you against diseases.
NAD+ BENEFITS AND ANTI-AGING MECHANICS
NAD⁺ Supports Energy Production
NAD⁺ was first discovered as an important part of the process that channels chemical energy from foods to the ATP fuel our cells require. Recent studies have revealed that NAD⁺ is itself a form of “energy currency” similar to Adenosine triphosphate (ATP), the source of energy for use and storage at the cellular level.
NAD⁺ Promotes Chromosome Stability
Our chromosomes are complex structures housing our DNA. Access to DNA strands for “reading out” genetic instructions require biochemical control of those proteins to make sure each gene functions properly.
But, like any complex molecular structure, chromosomes can become unstable. Eventually, this triggers errors in the ways our genes are interpreted—which ultimately contributes to deleterious changes in cell function and structure.
Aging is accelerated in the presence of increased chromosome instability. The enzymes involved in sustaining stable chromosomal structures require NAD⁺ in order to function properly.
NAD⁺ Promotes DNA Repair
Even though DNA is protected by its chromosomal shelter, it is highly vulnerable to damage. This can lead to broken DNA strands and mutations in crucial genes. Accumulated DNA damage contributes to the aging process and can result in specific lifespan-shortening diseases and poor immune function.
NAD⁺ Activates Sirtuins
Proteins called sirtuins are major regulators of cellular aging because they influence fundamental functions such as DNA repair and inflammatory responses. They also influence whether cells enter a replicative cycle or instead die a programmed death (apoptosis).
Compounds that activate sirtuins are eagerly sought as chemical “fountains of youth.” Familiar supplements like resveratrol and quercetin have been evaluated as promising sirtuin activators. NAD⁺ is required for sirtuins to function. Sirtuin activation has shown great promise in fighting cardiovascular disease and preserving aging brain function, but these longevity promoters cannot function without sufficient NAD⁺.
NAD⁺ Modulates Immune-Cell Signalling
As we age, our immune cells begin to lose their focus. Some become overactive, contributing to autoimmune disease, while others slow down, which increases the risk of infection. This process, called immunosenescence, is intimately related to mitochondrial function and energy balance, both of which depend on NAD⁺ activity. Intracellular levels of NAD⁺ regulate immune and inflammatory pathways, including the cytokine TNF-alpha, a critical signalling molecule.
NAD⁺ Is A Neurotransmitter
Neurotransmitters are brain chemicals that relay signals between nerve cells. In doing so, they help regulate body-wide functions such as mood, appetite, and stress. NAD⁺ has been found to meet all criteria for a neurotransmitter. Evidence for NAD⁺’s neurotransmitter function has now been found in intestinal and blood vessel smooth muscles, as well as in the brain itself. Research concludes that ample NAD⁺ nutrition appears essential for sustaining brain health.
NAD⁺ May Contribute To Longer Telomeres
NAD⁺ is required for functioning of sirtuin proteins that contribute to longevity—and specifically to maintaining the length of critical telomeres. Telomeres are stretches of repetitive DNA strands that cap the ends of chromosomes. Like the burning of a fuse, telomeres at the ends of our chromosomes steadily shorten every time a cell replicates itself. Once telomeres reach a critically short length, cell renewal virtually stops, leading to accelerated aging or death of the cell.
NAD⁺ Induces Energy-Intensive Enzymes
A universal feature of aging is the loss of cellular energy, which results in diminished ATP levels and inadequate cellular fuel necessary to power your body. One cause of this energy loss is a breakdown in the efficiency of the electron transport chain, the main pathway through which we extract energy from food (and of which NAD⁺ is an essential component). Disorders ranging from obesity and diabetes to bone loss have been associated with loss of this vital pathway.
CELLIFE NAD+ BOOST
Cellife NAD+ Boost is a new generation sustained release, complex formula containing Nicotinic acid and Nicotinamide. These nutrients are precursors to increase NAD+ levels.
Approved TGA Indications for Cellife NAD+ Boost include:
- Maintain and support body tissue repair and regeneration
- Helps decrease free radical damage to body cells
- Maintain and support energy levels
- Helps improve and promote body metabolism and metabolic rate
- Maintain and support healthy immune system function
- Helps maintain and support transport of oxygen in the body
- Antioxidant / Reduce free radicals formed in the body
- Maintain and support vitamin, mineral and nutrient levels in the body
- Helps support cellular uptake of vitamin, mineral and nutrients
- Supports healthy stress response in the body